发明名称 |
MODULATION OF MACROPHAGE ACTIVATION |
摘要 |
The invention is generally directed to promoting Ml-type (macrophage M1 polarization) immune response by administering a compound that modulates macrophage activation. The invention is directed to the use of an antibody able to bind to CSF-IR for modulating macrophage activation. The invention is also directed to methods for evaluating the dose efficacy of an antibody able to bind to CSF-IR in a patient by assessing the in vivo or in vitro activation of macrophages. The invention is further directed to post-treatment companion test and assays to assess the effect of an antibody able to bind to CSF-IR on a subject being treated. |
申请公布号 |
WO2013057281(A3) |
申请公布日期 |
2013.06.13 |
申请号 |
WO2012EP70805 |
申请日期 |
2012.10.19 |
申请人 |
TRANSGENE SA |
发明人 |
HAEGEL, HELENE;HALLET, REMY |
分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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