发明名称 |
Crystalline Peptide Epoxy Ketone Protease Inhibitors and the Synthesis of Amino Acid Keto-Epoxides |
摘要 |
The invention relates to crystalline peptide keto epoxide compounds, methods of their preparation, and related pharmaceutical compositions. This invention also relates to methods for the preparation of amino acid keto-epoxides. Specifically, allylic ketones are stereoselectively converted to the desired keto epoxides.
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申请公布号 |
US2013150290(A1) |
申请公布日期 |
2013.06.13 |
申请号 |
US201313757148 |
申请日期 |
2013.02.01 |
申请人 |
ONYX THERAPEUTICS, INC.;ONYX THERAPEUTICS, INC. |
发明人 |
PHIASIVONGSA PASIT;SEHL LOUIS C.;FULLER WILLIAM DEAN;LAIDIG GUY J. |
分类号 |
C07K5/107 |
主分类号 |
C07K5/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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