TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS

摘要

Compounds of Formula I are useful as antagonists of transient receptor potential melastatin 8 (TRPM8). They are useful in treating disorders and conditions such as migraines and neuropathic pain. Compounds of Formula I have the following structure: where in particular X1 and X 2 may be C or N, and R1 is a ring.