| 摘要 |
<p>The present invention relates to novel phytosphingosine derivatives and to a cosmetic composition comprising same for preventing and treating inflammatory skin diseases and hyperkeratosis diseases. More particularly, the present invention relates to the phytosphingosine derivatives of the above chemical formula 1, and to a cosmetic composition comprising the derivatives for preventing and improving inflammatory skin diseases and hyperkeratosis diseases. The phytosphingosine derivatives of the present invention are involved with transcription factors related to inflammation and hyperkeratosis diseases, the expression and generation of inflammatory mediators, signal transduction mechanisms, and the expression and activity of enzymes and the like, and thus are more effective in preventing, improving, and treating inflammatory skin diseases and hyperkeratosis diseases than existing phytosphingosines. Thus, the phytosphingosine derivatives of the present invention can be effectively used in preparing competitive cosmetics.</p> |
