发明名称 |
99mTc-LABELED TRIPHENYLPHOSPHONIUM DERIVATIVE CONTRASTING AGENTS AND MOLECULAR PROBES FOR EARLY DETECTION AND IMAGING OF BREAST TUMORS |
摘要 |
99mTc-labeled triphenylphosphonium contrasting agents that target the mitochondria and are useful for early detection of breast tumors using scintimammographic imaging. 99mTc-Mito10-MAG3 possesses advantageous radiopharmaceutical properties. The uptake in the myocardium is reduced by one to two orders of magnitude compared to 99mTc-MIBI. 99mTc-Mito10-MAG3 exhibits fast blood clearance, with a blood half-life of less than 2 minutes in rats. A diminished myocardial uptake combined with a prompt reduction of cardiovascular blood pool signal to facilitate improved signal-to-background ratios.
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申请公布号 |
US2013149240(A1) |
申请公布日期 |
2013.06.13 |
申请号 |
US201313753703 |
申请日期 |
2013.01.30 |
申请人 |
LOPEZ MARCOS;HARDY MICAEL JOEL;KALYANARAMAN BALARAMAN;ZHAO MING |
发明人 |
LOPEZ MARCOS;HARDY MICAEL JOEL;KALYANARAMAN BALARAMAN;ZHAO MING |
分类号 |
A61K51/08;C07K1/13;C07K5/10 |
主分类号 |
A61K51/08 |
代理机构 |
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地址 |
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