| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a compound having an amyloid β production inhibiting action and useful as a therapeutic agent of a disease induced by production, secretion and/or deposition of an amyloid β protein. <P>SOLUTION: The compound is represented by formula (I), wherein the ring A is a carbon cyclic group which may have a substituent or a heterocyclic group which may have a substituent; E is a lower alkylene or the like; X is S, O or NR<SP POS="POST">1</SP>; R<SP POS="POST">1</SP>is hydrogen or a lower alkyl; R<SP POS="POST">2a</SP>, R<SP POS="POST">2b</SP>, R<SP POS="POST">3a</SP>, R<SP POS="POST">3b</SP>, R<SP POS="POST">4a</SP>and R<SP POS="POST">4b</SP>are each independently hydrogen, halogen, hydroxy or the like; n and m are each independently an integer of 0 to 3; n+m is 1 or 3; and R<SP POS="POST">5</SP>is hydrogen, a lower alkyl which may have a substituent, or the like. <P>COPYRIGHT: (C)2013,JPO&INPIT |
