发明名称 |
METHOD OF CONTROLLING ADMINISTRATION OF CANCER ANTIGEN |
摘要 |
The present invention is directed to mammalian bi-specific T cells and methods for using these bi-specific T cells. More specifically, the invention relates to a method of controlling administration of cancer antigen to a subject by providing bi-specific T cells that express a viral antigen T cell receptor and a cancer antigen-specific chimeric receptors and triggering their activation by also administering antigen-presenting T-cells which express viral antigen. These bi-specific T cell clones are a source of effector cells that persist in vivo in response to stimulation with viral antigen, leading to long-term function after their transfer to patients with cancer and autoimmune diseases.
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申请公布号 |
US2013149337(A1) |
申请公布日期 |
2013.06.13 |
申请号 |
US201113248135 |
申请日期 |
2011.09.29 |
申请人 |
COOPER LAURENCE;JENSEN MICHAEL;CITY OF HOPE |
发明人 |
COOPER LAURENCE;JENSEN MICHAEL |
分类号 |
A61K35/14;A61K39/00;A61K39/145;A61K39/245;A61K48/00;C12N5/0783 |
主分类号 |
A61K35/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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