<p>Methods and composition for providing induced pluripotent stem (iPS) cells are provided. For example, in certain aspects methods including reprogramming B lymphocytes transformed by episomal vectors such as Epstein-Barr virus-based vectors are described. Furthermore, the invention provides induced pluripotent stem cells essentially free of exogenous elements and having B cell immunoglobin variable region rearrangement.</p>
申请公布号
EP2601289(A2)
申请公布日期
2013.06.12
申请号
EP20110815273
申请日期
2011.08.03
申请人
CELLULAR DYNAMICS INTERNATIONAL, INC.
发明人
THOMSON, JAMES;RAJESH, DEEPIKA;DICKERSON, SARAH, JANE;MACK, AMANDA;MILLER, MICHAEL