发明名称 |
Treatment of neurological or neurodegenerative disorders |
摘要 |
<p>The Invention relates to a protein or peptide consisting of a kringle portein or peptide and its use for the treatment of neurological or neurodegenerative disorders, in particular stroke. The invention relates also to an isolated antibody of fragment thereof which binds to the N-terminal domain of the NMDA receptor subunit NR1 (anti-NR1 antibody), whereas binding of the antibody or the fragment thereof prevents the cleavage of the extracellular domain of the NR1 subunit, or the fragment and its use for the treatment of neurological or neurodegenerative disorders, in particular stroke. The invention relates further to a pharmaceutical composition containing said kringle protein or peptide or anti-NR1 antibody.</p> |
申请公布号 |
EP2601966(A1) |
申请公布日期 |
2013.06.12 |
申请号 |
EP20130001189 |
申请日期 |
2010.01.29 |
申请人 |
PAION DEUTSCHLAND GMBH;INSERM |
发明人 |
PETERSEN, KARL-UWE;VIVIEN, DENIS;ALI, CARINE;MACREZ, RICHARD |
分类号 |
A61K38/49;A61K39/395;A61P25/00;C07K14/705;C07K16/28 |
主分类号 |
A61K38/49 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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