Inhibition of cis-platin induced ototoxicity

摘要

The invention describes diphenylhydramine (DPH) for treating ototoxicity in a subject, for inhibiting the formation of platinum adducts in a cell of the inner ear, and for preventing and/or inhibiting structural and functional damage in the inner ear. Furthermore, the invention describes an in vitro method for determining a subject's susceptibility for platinum induced ototoxicity and/or platinum induced nephrotoxicity and an in vitro method for screening a compound for inhibiting ototoxicity induced by a platinum complex as well as a kit useful for screening. The invention also describes a composition for treating cancer and concurrently inhibiting ototoxicity, nephrotoxicity and/or neurotoxicity. The invention further describes DPH for treating nephrotoxicity in a subject induced by a medication comprising a platinum complex.