发明名称 |
Dry powder formulation of azole derivative for inhalation |
摘要 |
<p>A spray dried-powder composition for inhalation comprising particles (X) containing (a) between 5 and 50% by weight of at least one azole derivative in amorphous state but not in crystalline structure and (b) at least one matricial agent to the composition selected from a group consisting of polyol such as sorbitol, mannitol and xylitol; a monosaccharides such as glucose and arabinose; disaccharide such as lactose, maltose, saccharose and dextrose; cholesterol, and any mixture thereof, wherein the composition provides a dissolution rate of said azole derivative of at least, 5 % within 10 minutes, 10 % within 20 minutes and 40 % within 60 minutes when tested in the dissolution apparatus type 2 of the United States Pharmacopoeia at 50 rotation per minute, 37 °C in 900 milliters of an aqueous dissolution medium adjusted at pH 1.2 and containing 0.3 % of sodium laurylsulfate.</p> |
申请公布号 |
EP2601973(A1) |
申请公布日期 |
2013.06.12 |
申请号 |
EP20110192851 |
申请日期 |
2011.12.09 |
申请人 |
LABORATOIRES SMB SA |
发明人 |
VANDERBIST, FRANCIS;SEBTI, THAMI;DEBOECK, ARTHUR;DURET, CHRISTOPHE;AMIGHI, KARIM;BAUDIER, PHILIPPE |
分类号 |
A61K47/14;A61K9/00;A61K47/26;A61K47/28 |
主分类号 |
A61K47/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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