Activation epitope of FcgammaRII (CD32), binding molecules that specifically bind the epitope and means and methods for the detection of the epitope, and uses of said epitope or said binding molecules

摘要

The present invention provides means and method for detecting an activation epitope on FcyRII (CD32) on Fcgamma (CD32) expressing cells. The presence of epitope on FcgammaRII (CD32) correlates with priming of the cell containing FcgammaRII (CD32) expressing said epitope. The invention further provides binding molecules specific for said activation epitope on FcgammaRII (CD32), and uses thereof in the detection of activated cells. Further uses are the treatment of individuals suffering from inflammation or at risk of suffering thereof. Also provided, among others, are uses for detecting and/or following an inflammation in an individual.