发明名称 |
Lytic peptides having anti-proliferative activity against prostate cancer cells |
摘要 |
Lytic peptides, including fusion peptides of lytic peptides conjugated with luteinizing hormone-releasing hormone or modified versions thereof to target luteinizing hormone-releasing hormone receptors, are disclosed. The lytic peptides show anti-proliferative activity against human prostate cancer cell lines, but are nontoxic to normal primary human prostate epithelial cells or to bone marrow stromal cells in co-culture. The lytic peptides have specificity for and anti-proliferative activity against prostate cancer tumor cells, and low toxicity for normal prostate cells, making the peptides useful in therapies for prostate cancer.
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申请公布号 |
US8461118(B2) |
申请公布日期 |
2013.06.11 |
申请号 |
US201113178042 |
申请日期 |
2011.07.07 |
申请人 |
YATES CLAYTON;JAYNES JESSE;TURNER TIMOTHY;TUSKEGEE UNIVERSITY |
发明人 |
YATES CLAYTON;JAYNES JESSE;TURNER TIMOTHY |
分类号 |
A61K38/00;A61K38/09;A61K38/16;A61K38/24 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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