发明名称 |
SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-.BETA.]INDOLES, METHODS FOR THE PRODUCTION AND USE THEREOF |
摘要 |
The invention relates to antagonists of 5-HT6 serotoninreceptors which simultaneously control the homeostasis of calcium ions in cells and is in the form of substituted 2,3,4,5-tetrahydro-1h-pyrido[4,3-b]indoles of general formula (1), wherein R1 is an aminogroup substituent selected form optionally substituted C1-C5 alkyl; R2 i is one or more substituents selected from hydrogen, halogen, C1-C3 alkyl, CF3 or OCF3; Ar is C1-C6 alkoxy non-substituted or substituted by halogen, C1-C6 alkyl, phenyl substituted byan aminogroup or trifluormethyl or optionally substituted aromatic 6-member heterocycle comprising 1-3 nitrogen atoms in a cycle; and W is an -CH2CH2- ethyl group, vinyl or acetenyl group. The novel compounds selected from the compounds of general formula 1, methods for the production thereof, pharmaceutical compositions and methods for the use thereof are also disclosed. |
申请公布号 |
CA2683453(C) |
申请公布日期 |
2013.06.11 |
申请号 |
CA20082683453 |
申请日期 |
2008.04.01 |
申请人 |
ALLA CHEM, LLC;IVASHCHENKO, ANDREY ALEXANDROVICH |
发明人 |
IVASHCHENKO, ANDREY ALEXANDROVICH;IVASHCHENKO, ALEXANDRE VASILIEVICH;TKACHENKO, SERGEY YEVGENIEVICH;FROLOV, YEVGENIY BORISOVICH;MITKIN, OLEG DMITRIEVICH;KRAVCHENKO, DMITRI VLADIMIROVICH;OKUN, ILYA MATUSOVICH;SAVCHUK, NIKOLAY FILIPPOVICH;LAVROVSKY, YAN |
分类号 |
C07D471/04;A61K31/437;A61P37/02;A61P37/08 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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