A MICROORGANISM HAVING L-AMINO ACIDS AND RIBOFLAVIN PRODUCTIVITY AND A METHOD OF PRODUCING L-AMINO ACIDS AND RIBOFLAVIN USING THE SAME

摘要

PURPOSE: A method for simultaneously producing L-amino acids and riboflavin is provided to conveniently produce feed and to reduce production cost. CONSTITUTION: A method for simultaneously producing L-lysine or L-threonine and riboflavin comprises: a step of culturing a microorganism which is modified to produce high concentration L-lysine or L-threonine, and riboflavin. Corynebacterium glutamicum(KCCM 11223P) is modified to maintain high concentration L-lysine production and enhance riboflavin production. [Reference numerals] (AA) Purine biosynthesis path; (BB) Pentose phosphorylation path; (CC) Ribulose-5-phosphate-3- epimerase; (DD) Xylose-5-phosphate; (EE) Corresponding process; (FF) Ribulose-5-phosphate; (GG) 3,4-dihydroxyl-2-butanone-4-phosphate; (HH) GPT-cyclohydrolase II; (II) 2,5-diamion-6-hydroxy-4-(5'- phosphoribosyl amino)pyrimidine; (JJ) Pyrimidine diaminase; (KK) 5-amino-6-(5'-phosphoribosyl amine)uracil; (LL) Pyrimidine reductase; (MM) 5-amino-6-(5'-phosphoribityl amine)uracil; (NN) Riboflavin synthase subunit beta; (OO) 6,7-dimethyl-8-ribityl azine; (PP) Riboflavin synthase subunit alpha; (QQ) Riboflavin