GENETIC MARKER FOR POLYCYSTIC OVARY SYNDROME (PCOS)

摘要

The present invention relates to a novel genetic marker for polycystic ovary syndrome (PCOS), and in particular to a method for diagnosing polycystic ovary syndrome (PCOS) or detecting a predisposition of a female subject to polycystic ovary syndrome (PCOS), comprising examining the human annexin A5 (ANXA5) promoter in a sample obtained from the female subject and to detect nucleotide exchanges therein. The present invention also relates to a nucleic acid sequence comprising a human annexin A5 (ANXA5) promoter, which promoter comprises specific nucleotide exchanges defined herein, for use in the methods disclosed herein. The present invention further relates to a kit for use in the diagnostic methods disclosed herein.