摘要 |
Disclosed is a single-use bioreactor bag design providing substantially equivalent maximum shear rate at the impeller tip and average or bulk shear rate over a range of power per unit working volume and rpm needed for bioculture processing. The uniformity in shear profile of the bag design providing a unique advantage when used as a scale-down or scale-up platform. Also disclosed is a linearly scalable, single- use, bioreactor system for use in carrying out a scalable biomanufacturing process, the system comprising two single-use bioreactor bags of different volumes, wherein the ratio H/D of the height of the working volume H to the diameter D of the tank, or of the bag is equal to about 1.5, and the bulk shear in each of the bags is substantially constant. |
申请人 |
XCELLEREX, INC.;TUOHEY, COLIN;DELOGGIO, TED;ERDENBERGER, THOMAS;CLAPP, KENNETH, P.;DAMREN, RICHARD;GALLIHER, PARRISH, M.;GUERTIN, PATRICK;LEE, JIYOUNG;FISHER, MICHAEL |
发明人 |
TUOHEY, COLIN;DELOGGIO, TED;ERDENBERGER, THOMAS;CLAPP, KENNETH, P.;DAMREN, RICHARD;GALLIHER, PARRISH, M.;GUERTIN, PATRICK;LEE, JIYOUNG;FISHER, MICHAEL |