| 摘要 |
Methods are described pertaining to the use of fractalkine (FKN, CX3CL1 ) and its receptor CX3CRI for treatment of neuroinflammation and/or neurodegeneration. Also included are methods for treatment of neuroinflammation and/or neurodegenerative diseases, comprising: administering to cells of a subject in need of such treatment, an adeno-associated virus that comprises a functional fractalkine gene operably linked to transcriptional control elements. The methods are used to treat or ameliorate Parkinson's disease, neuroinflammatory and/or neurodegenerative diseases including, but not limited to, Alzheimer's disease, epilepsy, aging, and traumatic brain injury. |
| 申请人 |
UNIVERSITY OF SOUTH FLORIDA;THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS;GEMMA, CARMELINA;BICKFORD, PAULA, C.;NASH, KEVIN, R.;MORGANTI, JOSH;BACHSTETTER, ADAM |
发明人 |
GEMMA, CARMELINA;BICKFORD, PAULA, C.;NASH, KEVIN, R.;MORGANTI, JOSH;BACHSTETTER, ADAM |
