发明名称 |
MARKER AND METHOD FOR DIAGNOSING DIARRHEA SYNDROME |
摘要 |
<p>The present invention relates in a first aspect to new nucleic acid molecules and peptides identifying and diagnosing diarrhea syndrome including chronic diarrhea and bowel diseases. In addition, methods are provided for identifying or diagnosing a potential risk for developing or having a diarrhea syndrome comprising identifying in a sample from a subject the presence or absence of a mutation at position 2519 of the gene encoding GC-C. Moreover, a kit is provided allowing identification or diagnosing a diarrhea syndrome including probes allowing the detection of mutations at position 2519 of the nucleic acid sequence encoding GC-C or for detecting a mutation at position 840 of GC-C. Moreover, a method for screening and/or identifying candidate molecules useful in prophylactically or therapeutically treating said diseases is provided. Finally, the present invention relates to metformin and/or a pharmaceutically acceptable salts thereof for use in the prophylactic or therapeutic treatment of diarrhea syndrome.</p> |
申请公布号 |
WO2013079721(A1) |
申请公布日期 |
2013.06.06 |
申请号 |
WO2012EP74247 |
申请日期 |
2012.12.03 |
申请人 |
BERGEN TEKNOLOGIOVERFOERING AS |
发明人 |
KNAPPSKOG, PER;FISKERSTRAND, TORUNN |
分类号 |
C07K14/435 |
主分类号 |
C07K14/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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