发明名称 |
MEK1 Mutation Conferring Resistance to RAF and MEK Inhibitors |
摘要 |
Nucleic acids and proteins having a mutant MEK sequence, and methods concerning identification of patients having resistance to treatment with anti-cancer agents, specifically inhibitors of RAF or MEK are provided. Methods of treatment and for optimizing treatment for patients having a mutation in a MEK1 sequence are also provided.
|
申请公布号 |
US2013143911(A1) |
申请公布日期 |
2013.06.06 |
申请号 |
US201113701889 |
申请日期 |
2011.06.09 |
申请人 |
GARRAWAY LEVI A.;EMERY CAROLINE;WAGLE NIKHIL;DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
GARRAWAY LEVI A.;EMERY CAROLINE;WAGLE NIKHIL |
分类号 |
A61K31/4745;C07H21/04;C12N9/12;C12Q1/68 |
主分类号 |
A61K31/4745 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|