发明名称 |
METHOD FOR IMPROVING THE SUCCESS RATE OF HEMATOPOIETIC STEM CELL TRANSPLANTS |
摘要 |
The technology described herein relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the genes encoding negative regulators of MHC expansion (e.g. AhR, Itch, Proxl and/or SH2B3), and methods of using such dsRNA compositions to inhibit expression of negative regulators of MHC expansion. The use of such compositions to provide, for example, enhanced quantitites and/or qualities of MHCs and/ or hematopoietic progenitor cells for transplantation and/ or to enhance engraftment of transplanted MHCs hematopoietic progenitor cells is described. |
申请公布号 |
WO2013019857(A3) |
申请公布日期 |
2013.06.06 |
申请号 |
WO2012US49156 |
申请日期 |
2012.08.01 |
申请人 |
ALNYLAM PHARMACEUTICALS, INC.;WONG, JAMIE;BETTENCOURT, BRIAN |
发明人 |
WONG, JAMIE;BETTENCOURT, BRIAN |
分类号 |
C12N15/113;A61K31/713;A61P7/00 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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