发明名称 COMPOUNDS AND THEIR USE AS IKACH BLOCKERS
摘要 The invention relates to compounds according to Formula I: or a pharmaceutically acceptable salt thereof, wherein m, n, R1, R2, R3, R4, R5, x and y are as defined herein. Compounds according to Formula I are pharmacologically effective as potassium channel inhibitors, in particular inhibitors of the acetylcholine operated inward rectifying potassium channel current (i.e. IKACh blockers), and are believed to be useful in the treatment of cardiac arrhythmias, in particular supraventricular tacharrhythmias, such as atrial fibrillation and atrial flutter.
申请公布号 US2013143858(A1) 申请公布日期 2013.06.06
申请号 US201313751459 申请日期 2013.01.28
申请人 ASTRAZENECA AB;ASTRAZENECA AB 发明人 BOSTROM JONAS;EMTENAS HANS;GRANBERG KENNETH;LLINAS ANTONIO;MOGEMARK MICKAEL
分类号 A61K31/445;A61K31/397;A61K31/40;C07D205/04;C07D207/08;C07D207/12;C07D211/38;C07D211/46;C07D295/13 主分类号 A61K31/445
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