发明名称 |
CHEMO- AND RADIATION-SENSITIZATION OF CANCER BY ANTISENSE TRPM-2 OLIGODEOXYNUCLEOTIDES |
摘要 |
Administration of antisense oligodeoxynucleotides (ODN) targeted against the testosterone-repressed prostate message-2 (TRPM-2) gene can reduce the amount of TRPM-2 in renal cell cancer (RCC) cells and other cancer cells, and as a result enhance chemosensitivity of these cells to chemotherapy agents and radiation. Thus, for example, the sensitivity of renal cell cancer cells to a chemotherapeutic agent can be increased by exposing renal cell cancer cells to a chemotherapeutic agent and an agent which reduces the amount of TRPM-2 in the renal cell cancer cells. This provides an improved method for treatment of renal cell cancer, which is generally resistant to treatment with known chemotherapy agents.
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申请公布号 |
US2013143944(A1) |
申请公布日期 |
2013.06.06 |
申请号 |
US201313737630 |
申请日期 |
2013.01.09 |
申请人 |
GLEAVE MARTIN;RENNIE PAUL S.;MIYAKE HIDEAKI;NELSON COLLEEN;ZELLWEGER TOBIAS;THE UNIVERSITY OF BRITISH COLUMBIA |
发明人 |
GLEAVE MARTIN;RENNIE PAUL S.;MIYAKE HIDEAKI;NELSON COLLEEN;ZELLWEGER TOBIAS |
分类号 |
A61K31/7125;A61K31/00;A61K31/337;A61K31/66;A61K31/704;A61K45/06;A61K48/00;C07K14/775 |
主分类号 |
A61K31/7125 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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