发明名称 |
COMPOUND LIBRARIES MADE THROUGH PHOSPHINE-CATALYZED ANNULATION/TEBBE/DIELS-ALDER REACTIONS |
摘要 |
A method for producing libraries of structurally and stereochemically diverse molecules that can be screened for biological or chemical activity. A library of 91 heterocyclic compounds composed of 16 distinct scaffolds was synthesized through a sequence of phosphine-catalyzed ring-forming reactions, Tebbe reactions, Diels-Alder reactions, and, in some cases, hydrolysis to illustrate the methods. Three compounds inhibiting migration of human breast cancer cells are identified from the library.
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申请公布号 |
US2013143916(A1) |
申请公布日期 |
2013.06.06 |
申请号 |
US201213673719 |
申请日期 |
2012.11.09 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIF;FENTEANY GABRIEL;THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
KWON OHYUN;FENTEANY GABRIEL |
分类号 |
A61K31/404;C12Q1/02;C40B30/04 |
主分类号 |
A61K31/404 |
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