| 发明名称 |
USE OF HISTONE ACETYLTRANSFERASE INHIBITORS AS NOVEL ANTI-CANCER THERAPIES |
| 摘要 |
The present invention provides methods for treating cancer comprising inhibiting the activity of p300/CBP histone acetyltransferase (HAT). Also provided are p300/CBP HAT inhibitors for treating a subject having cancer. In addition, the present invention includes biomarkers for p300/CBP HAT inhibition, which are used to i) monitor the effectiveness of cancer therapy, and ii) identify anti-cancer agents for use in combination therapy.
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| 申请公布号 |
US2013142887(A1) |
申请公布日期 |
2013.06.06 |
| 申请号 |
US201113520619 |
申请日期 |
2011.07.14 |
| 申请人 |
ALANI RHODA MYRA;COLE PHILIP A.;YAN GAI;BOWERS ERIN M.;THE JOHNS HOPKINS UNIVERSITY |
发明人 |
ALANI RHODA MYRA;COLE PHILIP A.;YAN GAI;BOWERS ERIN M. |
| 分类号 |
C12Q1/02;A61K31/4025;A61K31/4155;A61K31/4188;A61K33/24;A61N5/10;C07D405/06 |
主分类号 |
C12Q1/02 |
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