发明名称 |
Improvement of Factor VIII polypeptide titers in cell cultures |
摘要 |
The invention relates to a method for the production of a Factor VIII polypeptide, the method comprising the steps of a) culturing a mammalian cell expressing a Factor VIII polypeptide under conditions for expression of said Factor VIII polypeptide, said culturing conditions involving a cell culture medium comprising a C2-domain ligand, and b) isolating the expressed Factor VIII polypeptide from the mammalian cell by suitable means. |
申请公布号 |
AU2008248627(B2) |
申请公布日期 |
2013.06.06 |
申请号 |
AU20080248627 |
申请日期 |
2008.04.30 |
申请人 |
NOVO NORDISK A/S |
发明人 |
BOLT, GERT;JOHNSEN, LAUST BRUUN;STEENSTRUP, THOMAS DOCK;HILDEN, IDA |
分类号 |
C07K14/755 |
主分类号 |
C07K14/755 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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