发明名称 |
PROCESS FOR THE PREPARATION OF KEY INTERMEDIATES FOR THE SYNTHESIS OF STATINS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF |
摘要 |
<p>The invention relates to commercially viable process for the synthesis of key intermediates for the preparation of statins, in particular Rosuvastatin and Pitavastatin or respective pharmaceutically acceptable salts thereof. A new simple and short synthetic route for key intermediates is presented which benefits from the use of cheap and readily available starting materials, by which the conventionally most frequently used DIBAL-H as reducing agent can be avoided.</p> |
申请公布号 |
EP2598484(A1) |
申请公布日期 |
2013.06.05 |
申请号 |
EP20110746168 |
申请日期 |
2011.07.25 |
申请人 |
LEK PHARMACEUTICALS D.D. |
发明人 |
CASAR, ZDENKO;STERK, DAMJAN;JUKIC, MARKO |
分类号 |
C07C49/807;C07C45/68;C07D215/12;C07D215/14;C07D239/42;C07D239/46 |
主分类号 |
C07C49/807 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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