High affinity human antibodies to human nerve growth factor

摘要

A human antibody or antigen-binding fragment of an antibody which specifically binds human nerve growth factor (NGF) with K D of 5 pM or less and does not cross-react with neurotrophin-3 (NT-3). The antibodies are useful in treating pain, including inflammatory pain, post-operative incision pain, neuropathic pain, fracture pain, osteoporotic fracture pain, post-herpetic neuralgia, osteoarthritis, rheumatoid arthritis, cancer pain, pain resulting from bums, gout joint pain, as well as diseases, such as hepatocellular carcinoma, breast cancer, and liver cirrhosis.