发明名称 |
BIFUNCTIONAL PROTEIN ANCHORS |
摘要 |
The invention relates to the areas of immunology and vaccine delivery. More specifically, it relates to a bacterial vaccine delivery technology with built-in immunostimulatory properties which allows the immobilization of any antigen of interest, without prior antigen modification. Provided is an antigen-loaded immunogenic carrier complex comprising at least one bifunctional polypeptide attached to an immunogenic carrier, said bifunctional polypeptide comprising a peptidoglycan binding domain (PBD) through which the polypeptide is attached to said carrier, fused to an antigen binding domain (ABD) to which at least one antigen of interest is bound. Also provided is a pharmaceutical (e.g. vaccine) composition comprising an antigen-loaded immunogenic carrier complex of the invention. |
申请公布号 |
CA2615738(C) |
申请公布日期 |
2013.06.04 |
申请号 |
CA20062615738 |
申请日期 |
2006.07.20 |
申请人 |
APPLIED NANOSYSTEMS B.V. |
发明人 |
LEENHOUTS, CORNELIS JOHANNES;VAN ROOSMALEN, MAARTEN LEONARDUS;BOSMA, TJIBBE |
分类号 |
C07K14/335;A61K39/385;A61K39/39;A61P31/00;A61P33/00;A61P35/00;A61P37/00 |
主分类号 |
C07K14/335 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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