发明名称 |
Enrichment of a target sequence |
摘要 |
The present invention is directed to methods, compositions, software and devices for enriching low abundance alleles from a sample. The method is based in part on a modified nucleic acid amplification protocol that includes incubating the reaction mixture at a critical denaturing temperature or "Tc". By employing the present invention the current detection limits of all PCR-based technologies are greatly improved.
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申请公布号 |
US8455190(B2) |
申请公布日期 |
2013.06.04 |
申请号 |
US20080671295 |
申请日期 |
2008.07.31 |
申请人 |
MAKRIGIORGOS GERASSIMOS;DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
MAKRIGIORGOS GERASSIMOS |
分类号 |
C12Q1/68;C07H21/00;C07H21/02;C07H21/04 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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