| 摘要 |
<p>A method for preparing 2,2-difluoroethylamine of formula (I) CHF2CH2NH2 comprises steps (i) and (ii). In step (i), 2,2-difluoro-1-halogen ethane of formula (II) CHF2-CH2HAl, in which Hal stands for chlorine, bromine or iodine, is reacted with prop-2-en-1-amine of formula (III), to form N-(2,2-difluoroethyl)prop-2-en-1-amine of formula (IV), preferably in the presence of an acid scavenger. In step (ii), the allyl group is removed from the N-(2,2-difluoroethyl)prop-2-en-1-amine of formula (IV) obtained in step (i) to form 2,2-difluoroethylamine of formula (I) or a salt thereof.</p> |
