| 摘要 |
599175 Disclosed herein is a compound of formula I(a) and a compound of formula I(b) (thiostrepton analogues), a process for the production of said compounds comprising cultivating the microorganism Streptomyces species (PM0626271/MTCC 5447) under submerged aerobic conditions in a nutrient medium containing sources of carbon and nitrogen to produce the compounds in the fermented broth, and further comprising isolating the compounds from the fermented broth obtained after cultivating the microorganism Streptomyces species (PM0626271/MTCC5447); and purifying the compounds. Additionally disclosed is the use in the treatment of a disease caused by a bacterial infection wherein the bacterial infection is caused by bacteria belonging to Staphylococcus, Streptococcus, Enterococci, Bacillus or Mycobacterium species. |
