| 摘要 |
596616 Disclosed is a compound having the formula (1), wherein R1, R2, R3, R4 and R5 are defined herein, and a pharmaceutical composition comprising said compound additionally comprising a chemotherapeutic or anti-proliferative agent, an anti-inflammatory agent, an agent for treating atherosclerosis, or an agent for treating lung fibrosis. Specific embodiments of the compound include: 3-(difluoro(quinolin-6-yl)methyl)-N-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-amine, and 3-(difluoro(quinolin-6-yl)methyl)-N-(1,3-dimethyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-amine.
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