Humanised antibodies that bind and inhibit human DKK-1 protein and composition containing antibodies for treating DKK-1 associated diseases

摘要

595011 Disclosed is a human engineered DKK-1 antibody, comprising a light chain variable region (LCVR) and a heavy chain variable region (HCVR), wherein the LCVR comprises complementarity determining regions (CDRs) LCDR1, LCDR2, and LCDR3 and the HCVR comprises CDRs HCDR1, HCDR2 and HCDR3, wherein LCDR1 has the amino sequence of SEQ ID NO:5 (HASDSISNSLH), LCDR2 has the amino sequence of SEQ ID NO:47 (YXRQSXQ), LCDR3 has the amino sequence of SEQ ID NO:49 (QQSXSWPLH), HCDR1 has the amino sequence of SEQ ID NO:1 (GFTFSSYTMS), HCDR2 has the amino sequence of SEQ ID NO:2 (TISGGGFGTYYPDSVKG), and HCDR3 has the amino sequence of SEQ ID NO:44 (PGYXNYYFDI).