PIPERIDINYLAMINO-PYRIDAZINES AND THEIR USE AS FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS

摘要

THE PRESENT INVENTION RELATES TO 6-(PIPERIDIN-4-YLAMINO)PYRIDAZIN-3-CARBONITRILES OF FORMULA (I) THAT ARE FAST DISSOCIATING DOPAMINE 2 RECEPTOR ANTAGONISTS, PROCESSES FOR PREPARING THESE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING THESE COMPOUNDS AS AN ACTIVE INGREDIENT. THE COMPOUNDS FIND UTILITY AS MEDICINES FOR TREATING OR PREVENTING CENTRAL NERVOUS SYSTEM DISORDERS, FOR EXAMPLE SCHIZOPHRENIA, BY EXERTING AN ANTIPSYCHOTIC EFFECT WITHOUT MOTOR SIDE EFFECTS.