IMIDAZO [4,5-C]QUINOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF TUMORS AND/OR INFLAMMATION

摘要

The present disclosure relates to imidazo[4,5-c]quinoline derivatives of formula (I), process for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases mediated by phosphatidylinositol-3-kinase (PBK) and/or mammalian target of rapamycin (mTOR) and/or tumor necrosis factor-? (TNF-oc) and/or interleukin-6 (IL-6), particularly in the treatment of cancer and inflammation. Examples of such compounds include : 2-(4-(8-bromo-2-oxo-3-(phenylsulfonyl)-2,3-dihydro-1H-imidazoe 4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile, 2-(4-(8-bromo-2-oxo-3-tosyl-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile, 2-(4-(3-benzoyl-8-bromo-2-oxo-2,3-dihydro-1H-imidazo[ 4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile and 2-(4-(3-benzoyl-8-chloro-2-oxo-2,3-dihydro-1H-imidazo[4,5-c ]quinolin-1-yl)phenyl)-2-methylpropanenitrile.