| 摘要 |
COMPOUNDS HAVING GLUCOKINASE ACTIVATING EFFECTS AND BEING USEFUL AS TREATMENTS FOR DIABETES, WHICH ARE REPRESENTED BY THE FOLLOWING FORMULA (I): [WHEREIN X� REPRESENTS OXYGEN, ETC., X� REPRESENTS OXYGEN, ETC., R� REPRESENTS A GROUP ON RING A SUCH AS ALKYLSULFONYL, ETC., R� REPRESENTS C3-7 CYCLIC ALKYL OPTIONALLY SUBSTITUTED WITH A HALOGEN, ETC., R� REPRESENTS C3-7 CYCLIC ALKYL OPTIONALLY SUBSTITUTED WITH A HALOGEN, ETC., R� REPRESENTS A SUBSTITUENT ON RING B SUCH AS LOWER ALKYL, ETC., FORMULA (II): [CHEMICAL FORMULA 1] REPRESENTS 6- TO 10-MEMBERED ARYL, ETC., AND FORMULA (III):[FORMULA 1] REPRESENTS MONOCYCLIC OR BICYCLIC HETEROARYL OPTIONALLY HAVING ON RING B A SUBSTITUENT REPRESENTED BY R� ABOVE, WHEREIN THE CARBON ATOM OF RING B WHICH IS BONDED TO THE NITROGEN ATOM OF THE AMIDE GROUP OF FORMULA (I) FORMS A C=N BOND WITH THE NITROGEN ATOM OF THE RING, AS WELL AS THEIR PHARMACEUTICALLY ACCEPTABLE SALTS. |
