CITRULLINATED PEPTIDES FOR DIAGNOSING AND PROGNOSING RHEUMATOID ARTHRITIS; VIMENTIN FRAGMENTS

摘要

Patent No. 595310 Disclosed is a synthetic peptide comprising a first fragment of about 5 to about 50 contiguous amino acids of SEQ ID NO: 1 linked to at least a second fragment of about 5 to about 50 contiguous amino acids of SEQ ID NO: 1, wherein at least one residue of said first fragment is an arginine residue that is citrullinated, wherein at least one residue of said second fragment is an arginine residue that is citrullinated, and wherein the amino acids in said first fragment are not contiguous with the amino acids in said second fragment. SEQ ID NO: 1: MSTRSVSSSSYRRMFGGPGTASRPSSSRSYVTTSTRTYSLGSALRPSTSRSLYASSPGGVYATRSSAVRLRSSVPGVRLLQDSVDFSLADAINTEFKNTRTNEKVELQELNDRFANYIDKVRFLEQQNKILLAELEQLKGQGKSRLGDLYEEEMRELRRQVDQLTNDKARVEVERDNLAEDIMRLREKLQEEMLQREEAENTLQSFRQDVDNASLARLDLERKVESLQEEIAFLKKLHEEEIQELQAQIQEQHVQIDVDVSKPDLTAALRDVRQQYESVAAKNLQEAEEWYKSKFADLSEAANRNNDALRQAKQESTEYRRQVQSLTCEVDALKGTNESLERQMREMEENFAVEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESRISLPLPNFSSLNLRETNLDSLPLVDTHSKRTLLIKTVETRDGQVINETSQHHDLE