发明名称 |
ANTIGEN-BINDING MOLECULE CAPABLE OF BINDING TO TWO OR MORE ANTIGEN MOLECULES REPEATEDLY |
摘要 |
116The present inventors discovered that antibodies having weaker antigen-binding activity at the early endosomal pH in comparison with that at the pH of plasma are capable of binding to multiple antigen molecules with a single antibody molecule, have long half-lives in plasma, and have improved durations of time in which they can bind to antigen. 10 (No suitable figure) |
申请公布号 |
SG189775(A1) |
申请公布日期 |
2013.05.31 |
申请号 |
SG20130027180 |
申请日期 |
2009.04.10 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
IGAWA, TOMOYUKI;ISHII, SHINYA;MAEDA, ATSUHIKO;NAKAI, TAKASHI |
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