POTENT CONJUGATES AND HYDROPHILIC LINKERS

摘要

POTENT CONJUGATES AND HYDROPHILIC LINKERSLinkers for binding drugs to cell binding agents are modified to hydrophilic linkers by incorporating a polyethylene glycol spacer. The potency or the efficacy of the cell-binding agent-drug conjugates is surprisingly enhanced several folds in a variety of cancer cell types, including those expressing a low number of antigens on the cell surface or cancer cells that are resistant to treatment.FIGURE 1