METHODS FOR DETERMINING ANTI-DRUG ANTIBODY ISOTYPES

摘要

The present invention provides assay methods for the determination of one or more anti-drug antibody (ADA) isotypes in a sample. As a non-limiting example, the assays of the present invention are particularly useful for determining different ADA isotypes in samples from ADA-positive patients receiving an anti-TNFαdrug such as REMICADETM (infliximab) or HUMIRATM (adalimumab). The present invention also provides methods for optimizing therapy and/or reducing toxicity in subjects receiving TNFαinhibitors for the treatment of TNFα-mediated disease or disorders.