IMPROVED METHOD FOR PREPARING DIPEPTIDYL PEPTIDASE-IV INHIBITOR AND INTERMEDIATE

摘要

Patent No. 595542 Disclosed is a method for preparing dipeptidyl peptidase-IV inhibitor represented by Chemical Formula 1, the method comprising: (Step 1) preparing a compound represented by Chemical Formula 4 by bonding a compound represented by Chemical Formula 2 and a compound represented by Chemical Formula 3 with peptide bond by reacting them using triphenylphosphine, bis(2,2'-benzothiazolyl)disulfide, and a base in the presence of a reaction solvent; and (Step 2) preparing a compound represented by Chemical Formula 1 by removing an amine-protecting group of the compound represented by Chemical Formula 4 produced in the above Step 1.