发明名称 |
PROCESS FOR THE PREPARATION OF IBODUTANT (MEN15596) AND RELATED INTERMEDIATES |
摘要 |
This invention relates to a novel process for synthesizing the product ibodutant shown in the figure below, consisting of a small number of high-yield steps involving reagents and solvents with low environmental impact, characterized by the coupling of two portions, compounds (3) and (4), one of which (3) is synthesized by coupling of 6-methyl-2-benzo[b]thiophenecarboxylic acid (1) with 1-amino-alpha-alpha-cyclopentan carboxylic acid and subsequent cyclization with oxazolone, while the other, compound (4), is obtained from suitable highly selective functionalizations of 4-aminomethylpiperidine (2). |
申请公布号 |
HRP20130380(T1) |
申请公布日期 |
2013.05.31 |
申请号 |
HR2013P000380T |
申请日期 |
2013.05.02 |
申请人 |
MALESCI ISTITUTO FARMACOBIOLOGICO S. P. A. |
发明人 |
BONACCORSI, FABRIZIO;FEDI, VALENTINA;GIANNOTTI, DANILO |
分类号 |
C07D409/12;A61K38/05;A61P25/00 |
主分类号 |
C07D409/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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