发明名称 |
MELT-EXTRUDED SOLID DISPERSIONS CONTAINING AN APOPTOSIS-INDUCING AGENT |
摘要 |
<p>A pro-apoptotic solid dispersion comprises, in essentially non-crystalline form, a Bcl-2 family protein inhibitory compound of Formula I as defined herein, dispersed in a solid matrix that comprises (a) a pharmaceutically acceptable water-soluble polymeric carrier and (b) a pharmaceutically acceptable surfactant. A process for preparing such a solid dispersion comprises subjecting to elevated temperature the compound of Formula I, the water-soluble polymeric carrier and the surfactant, to provide an extrudable semi-solid mixture; extruding the semi-solid mixture; and cooling the resulting extrudate to to provide a solid matrix comprising the polymeric carrier and the surfactant and having the compound dispersed in essentially non-crystalline form therein. The solid dispersion is suitable for oral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bcl-2 family proteins, for example cancer or an immune or autoimmune disease.</p> |
申请公布号 |
SG189477(A1) |
申请公布日期 |
2013.05.31 |
申请号 |
SG20130029913 |
申请日期 |
2011.10.05 |
申请人 |
ABBVIE INC.;ABBOTT GMBH & CO.KG |
发明人 |
ROESCH, ESTHER;HOELIG, PETER;LINDLEY, DAVID J.;SANZGIRI, YESHWANT D.;TONG, PING |
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