MODIFIED PROTOZOAN EXPRESSING AT LEAST TWO VARIABLE SURFACE PROTEINS (VSP), A VACCINE COMPRISING IT AND PROCEDURES, USES, AND METHODS THEREOF

摘要

Disclosed is a modified Giardia lamblia parasite wherein a gene encoding Dicer, a gene encoding RNA-dependant RNA-polymerase (RdRP), or both have been silenced, and wherein said modified Giardia lamblia comprises simultaneous expression on its surface of more than one variable surface protein (VSP).