发明名称 |
Preselection of subjects for therapeutic treatment based on hypoxic status |
摘要 |
The present invention provides methods for the preselection of a subject for therapeutic treatment with an agent based on modulated levels of hypoxia in cancerous cells in the subject. In one embodiment, the invention provides methods for the preselection of a subject for therapeutic treatment with an agent based on modulated levels of lactate dehydrogenase (LDH) in a cell, e.g., a cancerous cell. The invention also provides methods for treating cancer in a subject by administering an effective amount of an agent to the subject, wherein the subject has been selected based on a modulated level of hypoxia. The invention further provides kits to practice the methods of the invention. |
申请公布号 |
AU2011329681(A1) |
申请公布日期 |
2013.05.30 |
申请号 |
AU20110329681 |
申请日期 |
2011.11.18 |
申请人 |
SYNTA PHARMACEUTICALS CORP. |
发明人 |
BLACKMAN, RONALD K.;VUKOVIC, VOJO |
分类号 |
A61K31/4196;A61K31/395;A61K31/436;A61K31/437;A61K31/4439;A61K31/502;A61K31/506;A61K31/517;A61K39/395;A61P35/00 |
主分类号 |
A61K31/4196 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|