| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide compounds which inhibit the expression of specific human genes, and pharmaceutical compositions comprising such compounds and a pharmaceutically acceptable carrier. <P>SOLUTION: The present invention provides inhibitors of an apoptotic gene selected from the group consisting of TP53BP2, LRDD, CYBA, ATF3, CASP2, NOX3, HRK, CIQBP, BNIP3, MAPK8, MAPK14, RAC1, GSK3B, P2RX7, TRPM2, PARG, CD38, STEAP4, BMP2, CX43, TYROBP, CTGF, SPP1, RTN4R, ANXA2, RHOA, and DUOX1. The inhibitor is selected from the group consisting of siRNA, shRNA, an aptamer, an antisense molecule, miRNA, a ribozyme, and an antibody. In the presently preferred embodiments, the inhibitor is siRNA. <P>COPYRIGHT: (C)2013,JPO&INPIT |
