RECOMBINANT BUTYRYLCHOLINESTERASES AND TRUNCATES THEREOF
摘要
Isolated nucleic acids encoding polypeptides that exhibit butyrylcholinesterase (BChE) enzyme activity are disclosed, along with molecular criteria for preparing such nucleic acids, including codon optimization. Methods of preparing modified and/or truncated BChE molecules having selected properties, especially selective formation of monomers, are also described. Vectors and cells containing and/or expressing the nucleic acids are also disclosed.
申请公布号
WO2011084145(A3)
申请公布日期
2013.05.30
申请号
WO2010US03225
申请日期
2010.12.21
申请人
PHARMATHENE, INC.;YIM, KALVIN;DANSO, STEVEN;HAUSKNECHT, EDWARD