发明名称 |
Detection of Fusobacterium in a gastrointestinal sample to diagnose gastrointestinal cancer |
摘要 |
Fusobacterium is a genus of gram-negative, filamentous, anaerobic bacteria found as normal flora in the mouth and large bowel, and often in necrotic tissue. A comparison of microbial ribonucleic acids (RNA) between colorectal carcinoma (CRC) tissue and adjacent normal control tissue found the over-representation of F. nucleatum in CRC tissue. RNA abundance was measured by polymerase chain reaction (PCR)-amplifying RNA from the tissue, constructing libraries, sequencing the RNA in the libraries, pairing sequences from CRC and normal tissue, and quantifying RNA abundance. Detection of Fusobacterium in a gastrointestinal sample is indicative of gastrointestinal cancer. |
申请公布号 |
AU2011313763(A1) |
申请公布日期 |
2013.05.30 |
申请号 |
AU20110313763 |
申请日期 |
2011.10.04 |
申请人 |
BRITISH COLUMBIA CANCER AGENCY BRANCH;ALLEN-VERCOE, EMMA |
发明人 |
ALLEN-VERCOE, EMMA;HOLT, ROBERT;MOORE, RICHARD;WARREN, RENE |
分类号 |
C12Q1/18;A61B10/00;A61K39/114;A61P31/04;A61P35/00;A61P37/04;C12Q1/02;C12Q1/04;C12Q1/68;G01N33/50;G01N33/569;G01N33/574 |
主分类号 |
C12Q1/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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