| 摘要 |
<p>The invention relates to a method of producing a delivery device for delivering a chemical compound. The method comprises: i) providing an interpenetrating polymer substrate (IP substrate) comprising a first continuous polymer comprising rubber and a second polymer comprising hydrogel or a hydrogelable precursor, where the second polymer is interpenetrating in the first polymer; ii) providing the chemical compound and a loading solvent for the chemical compound iii) loading the IP substrate with the chemical compound by subjecting the IP substrate to the loading solvent comprising the chemical compound under conditions where the loading solvent at least partially swells the second polymer. The chemical compound, the second polymer and the loading solvent are selected such that the work of adhesion (Whc) between the second polymer and the chemical compound during at least a part of the loading is at least about 0 J/m2. The invention further comprises delivery devices comprising an IP substrate comprising a first continuous polymer comprising silicone, a second continuous polymer comprising second polymer and a chemical compound arranged to be released from the delivery device upon contact with aqueous liquid or moisture, wherein at least about 50 mol% or less of the chemical compound in the delivery device requires an energy of 30 J/mol or less to be released or wherein a part of the chemical compound is adhered to the first continuous polymer, a part of the chemical compound is adhered to the second polymer and the remaining part of the chemical compound is present as free compound in the first and second polymer, dissolved or as crystals.</p> |
